Melrose Plantation is a unique site founded by Louis Metoyer, the son of African slave Marie Thérèse Coincoin, that reflects the birth of a culture known today as the Cane River Creole. The Metoyer family became the leading family in the community of Isle Brevelle, known for its population of gens de couleur libre, or free people of color, who thrived along the Cane River.

In addition, Melrose Plantation is the home of the world-famous African American folk artist Clementine Hunter. A collection of her work is available for viewing, including her famous African House Murals that depict life on Melrose Plantation.

Melrose Plantation is a member of the Historic Artists' Homes & Studios program.