The Florence Griswold Museum is a nationally recognized center for American art and history and a member of the Historic Artists' Homes & Studios Program. The 13-acre site on the Lieutenant River in the historic town of Old Lyme, Connecticut, offers visitors a variety of art, history, and nature in a New England village setting. Its cornerstone, the Florence Griswold House, is a fine example of a Late Georgian-style house with Federal-style features designed in 1817 by Samuel Belcher.

In 2006, the Museum completed restoration of the boardinghouse to its 1910 heyday, when American artists such as Childe Hassam and Willard Metcalf, as well as leading public figures such as Woodrow Wilson, called it their summer home. Between 1899 and the 1930s, over 135 American artists boarded at the Florence Griswold House when it was the center of Impressionism in America. Leading artists painted a panel on the walls or doors of the house. The resulting interior, an ensemble of 43 panels, represents the most complete expression of an American art colony.

Other facilities include the Robert and Nancy Krieble Gallery, which hosts changing exhibitions of American art and culture; the Hartman Education Center, used for education programs for all ages; the Rafal Landscape Center, a renovated barn where visitors learn about the landscape’s cultural importance; and the c.1920 William Chadwick Studio, an example of a Lyme Art Colony artist studio.

Visitors enjoy "Miss Florence's" restored garden and orchard, which were the subject of so many paintings by the Lyme Art Colony artists.