The La Pointe-Krebs House was constructed in the fall of 1757, according to the recently completed dendrochronological study performed by the University of Southern Mississippi. That date makes it not only the oldest building in the state of Mississippi but also the oldest standing structure confirmed by science in the entire Mississippi River Valley (between the Appalachians and the Rockies).

It is one of two remaining French Colonial structures on the Gulf Coast and the only extant example of a tabby structure on the entire Gulf Coast. It has existed in regimes of and been owned and occupied by German, French, Spanish, English, and American occupants through its lifetime. It serves as the ancestral home of the Krebs Family of America. It also represents a tangible tie to the explorations of Pierre Lemoyne Sieur D'Iberville and Jean Baptiste Lemoyne Sieur Bienville in and around 1699 during the original European settling of the Gulf Coast.